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[考试辅导] 医学考博每日一读:US panel approves anti-HIV pill

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发表于 2012-7-20 22:52:00 | 显示全部楼层 |阅读模式
A panel of US health experts has for the first time backed a drug to prevent HIV infection in healthy people.
6 `0 t4 ?6 X( V7 b2 }1 [7 UThe panel recommended US regulators approve the daily pill, Truvada, for use by people considered at high risk of contracting the Aids virus.+ p, B# B, n+ i7 @9 t5 r# G' S3 p
The US Food and Drug Administration (FDA) is not required to follow the panel's advice, but it usually does.3 @, p% B$ |( j0 @" o& M( t5 X
Some health workers and groups active in the HIV community have opposed the approval of the drug.
; s/ c6 B) f* P# A0 @/ N7 E5 fHowever, correspondents say the move could prove to be a new milestone in the fight against HIV/Aids./ i/ F' x. P4 G" t$ S1 y
Truvada is already approved by the FDA for people who are HIV-positive, and is taken along with existing anti-retroviral drugs.9 ?5 q5 p& B4 d$ Y) V
Studies from 2010 showed that Truvada, made by California-based Gilead Sciences, reduced the risk of HIV in healthy gay men - and among HIV-negative heterosexual partners of people who are HIV positive - by between 44% and 73%.
" J8 T& R, U+ S' g3 I, AJune decision ; e& J9 \" d; b3 N
The Antiviral Drugs Advisory Committee, which advises the FDA, voted 19-3 in favour of prescribing the drug to the highest risk group - non-infected men who have sex with multiple male partners.( h& \/ q* U2 E( o9 P8 C8 G  R
They also approved it, by majority votes, for uninfected people with HIV-positive partners and for other groups considered at risk of acquiring HIV through sexual activity.
+ @+ B/ D, H, U+ I+ c# |% O6 Z& ^$ ~The votes followed an 11-hour meeting of the panel in Silver Spring, Maryland, and a lengthy public comments session.
8 N8 v7 P8 Y& A% H  A! }1 FOpposition to the prospect of approving the drug is based on concerns that users could gain a false sense of security, and fears of a drug-resistant strain of HIV.
$ u( M4 Y9 d$ \6 Y9 |There is also concern that the high cost of Truvada could divert limited funding from more cost-effective options.6 Q* J3 y- V* x# F% A
"We need to slow down. I care too much about my community not to speak my concerns," said Joey Terrill, of the Aids Healthcare Foundation, which campaigned against the drug's approval.
: G6 C0 O- x3 A* _4 W/ SNurse Karen Haughey told the panel: "Truvada needs to be taken every day, 100% of the time, and my experience as a registered nurse tells me that won't happen. 0 d2 p, g, \2 b+ ^! L! |) D* U
"In my eight years, not one patient that I've cared for has been 100% adherent.") T' L1 F2 {8 N  ]8 W
But others welcomed the panel's recommendation.6 u$ g" a, K+ T0 `# E: I
"This brings us closer to a watershed for global HIV prevention efforts," said Mitchell Warren, executive director of the Aids Vaccine Advocacy Coalition, after the vote., z' G0 L1 H7 U: s' h- j. F
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