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[考试辅导] 医学考博每日一读:US panel approves anti-HIV pill

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发表于 2012-7-20 22:52:00 | 显示全部楼层 |阅读模式
A panel of US health experts has for the first time backed a drug to prevent HIV infection in healthy people.# B- r3 I+ g/ f* N0 m" Y
The panel recommended US regulators approve the daily pill, Truvada, for use by people considered at high risk of contracting the Aids virus.  p1 L7 e2 C* d; a. ^
The US Food and Drug Administration (FDA) is not required to follow the panel's advice, but it usually does.7 e3 b6 D" O" V3 \3 ?
Some health workers and groups active in the HIV community have opposed the approval of the drug.0 Q6 d- s' O1 Y* |2 a$ @% b
However, correspondents say the move could prove to be a new milestone in the fight against HIV/Aids.
$ ^$ W8 F  h6 P) T8 P. R7 ~Truvada is already approved by the FDA for people who are HIV-positive, and is taken along with existing anti-retroviral drugs./ q6 f- F: r8 ]- U" `5 |. }
Studies from 2010 showed that Truvada, made by California-based Gilead Sciences, reduced the risk of HIV in healthy gay men - and among HIV-negative heterosexual partners of people who are HIV positive - by between 44% and 73%.
' k5 E0 o: D2 q; I" r# UJune decision $ j2 I! \$ C0 Y, U: X
The Antiviral Drugs Advisory Committee, which advises the FDA, voted 19-3 in favour of prescribing the drug to the highest risk group - non-infected men who have sex with multiple male partners.5 g7 x3 }( f8 j/ C1 r
They also approved it, by majority votes, for uninfected people with HIV-positive partners and for other groups considered at risk of acquiring HIV through sexual activity.. s9 A1 r( g. t
The votes followed an 11-hour meeting of the panel in Silver Spring, Maryland, and a lengthy public comments session.. J1 l# J6 [2 |) D3 ]6 }$ R( ~
Opposition to the prospect of approving the drug is based on concerns that users could gain a false sense of security, and fears of a drug-resistant strain of HIV.
0 _& R& k9 `" \: m$ I' ]There is also concern that the high cost of Truvada could divert limited funding from more cost-effective options.. F* X1 M# U5 T0 C: |3 G
"We need to slow down. I care too much about my community not to speak my concerns," said Joey Terrill, of the Aids Healthcare Foundation, which campaigned against the drug's approval.
0 @  \8 t6 ?; M( f6 Z# K+ w( YNurse Karen Haughey told the panel: "Truvada needs to be taken every day, 100% of the time, and my experience as a registered nurse tells me that won't happen.
% B" E' k% s& U, r+ s7 X"In my eight years, not one patient that I've cared for has been 100% adherent."$ p+ U$ j9 G6 S; A* t
But others welcomed the panel's recommendation.
6 y1 m' `/ S/ H7 A"This brings us closer to a watershed for global HIV prevention efforts," said Mitchell Warren, executive director of the Aids Vaccine Advocacy Coalition, after the vote.
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