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[考试辅导] 医学考博每日一读:Third of malaria drugs 'are fake'

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发表于 2012-7-20 22:52:00 | 显示全部楼层 |阅读模式
A third of malaria drugs used around the world to stem the spread of the disease are counterfeit, data suggests.
1 K/ H9 a5 B% b& cResearchers who looked at 1,500 samples of seven malaria drugs from seven countries in South East Asia say poor-quality and fake tablets are causing drug resistance and treatment failure.& p$ ?  K% m9 }$ b7 ]. l% w% ]; r0 j
Data from 21 countries in sub-Saharan Africa including over 2,500 drug samples showed similar results.
/ b( o( `9 j; P$ X) ]: @, }Experts say The Lancet Infectious Diseases research is a "wake-up call".$ U! j$ G( S1 B. P; B
The US researchers from the Fogarty International Center at the National Institutes of Health who carried out the work believe the problem may even be much greater than data suggests.
, X' ~# k" A- Q6 t" o( q; ^"Most cases are probably unreported, reported to the wrong agencies, or kept confidential by pharmaceutical companies," say the researchers.2 u* l$ ]6 ?+ G" t. ~. Y( |+ @( D
No large studies of drug quality have been carried out in China or India - countries that house a third of the world's population and are a "probable" source of many counterfeit drugs as well as genuine antimalarial medicines, they say.
& n8 E% q1 M8 ]2 fLead researcher Gaurvika Nayyar stressed that 3.3 billion people were at risk of malaria, which is classified as endemic in 106 countries.
+ Y& E3 l7 \# ?# c) v0 a"Between 655,000 and 1.2 million people die every year from Plasmodium falciparum infection," he said., j5 H+ n* B  s- M' k2 Q  o9 C
"Much of this morbidity and mortality could be avoided if drugs available to patients were efficacious, high quality, and used correctly."
9 C4 A+ I, x, h' ~" ]In parts of the world where malaria is prevalent, antimalarial drugs are widely distributed and self-prescribed, both correctly and incorrectly, say the researchers.
& n" \) S+ N( c4 R# |. OThe study found there are insufficient facilities to monitor the quality of antimalarial drugs and poor consumer and health-worker knowledge about the therapies. ; n  O+ ^& h& U% _
And there is a lack of regulatory oversight of manufacturing and little punitive action for counterfeiters.
% u4 A0 e* v+ \" g0 j* aDespite this, malaria mortality rates have fallen by more than 25% globally since 2000, and by 33% in the WHO African Region.6 w. ]8 K: J" w( A- \
But the World Health Organization says maintaining current rates of progress will not be enough to meet global targets for malaria control.
/ K7 e) d2 {" y! N) eIt is calling for renewed investment in diagnostic testing, treatment, and surveillance for malaria.5 o- q8 f7 r) q! v( m1 H' `
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