2012年雅思阅读考试考前冲刺试题（14）

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2012年雅思阅读考试考前冲刺试题（14）
1.The failure of a high-profile cholesterol drug has thrown a spotlight on the complicated machinery that regulates cholesterol levels.But many researchers remain confident that drugs to boost levels of 'good' cholesterol are still one of the most promising means to combat spiralling heart disease.
: ]" M, q. I2 S- W5 @. M0 g　　2.Drug company Pfizer announced on 2 December that it was cancelling all clinical trials of torcetrapib，a drug designed to raise heart-protective high-density lipoproteins (HDLs).In a trial of 15000 patients，a safety board found that more people died or suffered cardiovascular problems after taking the drug plus a cholesterol-lowering statin than those in a control group who took the statin alone.
# \- b1 t; |1 @2 d. C　　3.The news came as a kick in the teeth to many cardiologists because earlier tests in animals and people suggested it would lower rates of cardiovascular disease."There have been no red flags to my knowledge," says John Chapman，a specialist in lipoproteins and atherosclerosis at the National Institute for Health and Medical Research (INSERM) in Paris who has also studied torcetrapib."This cancellation came as a complete shock."

　　4.Torcetrapib is one of the most advanced of a new breed of drugs designed to raise levels of HDLs，which ferry cholesterol out of artery-clogging plaques to the liver for removal from the body.Specifically，torcetrapib blocks a protein called cholesterol ester transfer protein (CETP)，which normally transfers the cholesterol from high-density lipoproteins to low density，plaque-promoting ones.Statins，in contrast，mainly work by lowering the 'bad' low-density lipoproteins.首页 1 2 3 4尾页

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　Under pressure</p>
, W7 X( L" y/ r0 V) Y　　5.Researchers are now trying to work out why and how the drug backfired，something that will not become clear until the clinical details are released by Pfizer.One hint lies in evidence from earlier trials that it slightly raises blood pressure in some patients.It was thought that this mild problem would be offset by the heart benefits of the drug.But it is possible that it actually proved fatal in some patients who already suffered high blood pressure.If blood pressure is the explanation，it would actually be good news for drug developers because it suggests that the problems are specific to this compound.Other prototype drugs that are being developed to block CETP work in a slightly different way and might not suffer the same downfall.1  2 3 4尾页

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Questions 1-7</p>　　This passage has 7 paragraphs 1-7.
　　Choose the correct heading for each paragraph from the list of headings below.
6 e8 Z& O; y  Q" |9 C2 G/ E　　Write the correct number i-ix in boxes 1-7 on your answer sheet.
　　List of Headings
. F5 s( V+ a$ }# [　　i.How does torcetrapib work?
　　ii.Contradictory result prior to the current trial
0 N- H/ a6 F* t. i+ h1 t/ N　　iii.One failure may possibly bring about future success
　　iv.The failure doesn't lead to total loss of confidence
" v4 G$ ]" K# I! ]' W　　v.It is the right route to follow
. h# t0 }+ Q9 t　　vi.Why it's stopped
　　vii.They may combine and theoretically produce ideal result
　　viii.What's wrong with the drug
6 r' Y9 P7 x$ w4 w2 c9 {2 X　　ix.It might be wrong at the first place
　　Example answer
　　Paragraph 1 iv
　　1.Paragraph 2
$ M0 T& {3 v$ ?: ]7 R& F　　2.Paragraph 3
　　3.Paragraph 4
　　4.Paragraph 5
　　5.Paragraph 6
　　6.Paragraph 7
　　Questions 7-13
+ r2 o+ }# j1 q% y; k. A8 i　　Match torcetrapib，HDLs，statin and CETP with their functions (Questions 8-13)..
! S/ Q+ Z  x) V# p5 T" A. G　　Write the correct letter A，B，C or D in boxes 8-13 on your answer sheet.
! q# a* e/ C' f, s" o　　NB You may use any letter more than once.
　　7.It has been administered to over 10,000 subjects in a clinical trial.
; H. w. Y8 {& T. s1 m5 G　　8.It could help rid human body of cholesterol.中华考试网
　　9.Researchers are yet to find more about it.
1 X, g& q9 q4 \1 H/ p* F　　10.It was used to reduce the level of cholesterol.
6 d: y1 L- N$ S8 y　　11.According to Kashyap，it might lead to unwanted result if it's blocked.
1 p9 c, X4 K% Z/ G4 q8 u　　12.It produced contradictory results in different trials.
　　13.It could inhibit LDLs.
　　List of choices
, p$ Z9 M/ l2 D6 c, }) \　　A.Torcetrapic
　　B.HDLS
5 O9 ~2 d# U* {. U+ h' h　　C.Statin

　　D.CETP首页1 2  3 4尾页

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Suggested Answers and Explanations</p>　　1.vi
　　2.ii
; T1 w$ i& W# J% T. G9 y　　3.vii 本段介绍了torcetrapib和statin的治病原理，但是同时短语“in contrast”与之前第二段后半段的内容呼应，暗示了这两种药在理论上能相辅相成，是理想的搭配。第一个选项无法涵盖整段意义，故选择i是错误的。
- q0 W  U) g9 G0 U　　4.iii 本段分析了可能导致torcetrapibl临床试验失败的原因，后半段指出如果以上推测正确，那么未来的药物可借鉴这个试验，设法避免torcetrapib的缺陷，研制出有效的药物。viii选项无法涵盖后半段的意思。

) `; U0 u5 l! J' r$ N　　5.ix 见首句。1 2 3  4 尾页